血型影響你的記憶力
時(shí)間：2014-09-15 09:41:56 來(lái)源：轉(zhuǎn)化醫(yī)學(xué)網(wǎng) 點(diǎn)擊：
AB是最常見的血型，占美國(guó)總?cè)丝诘?％左右。研究發(fā)現(xiàn)，與其他血型的人相比，AB型血的人有82％的可能性發(fā)展有思維和記憶問(wèn)題、老年癡呆癥。
該研究是一項(xiàng)大型研究，涉及超過(guò)30,000人，平均隨訪研究3.4年。這些人在研究開始時(shí)沒(méi)有記憶或思考功能問(wèn)題，但在研究過(guò)程中，研究確定了495名參與者發(fā)生思維和記憶問(wèn)題或認(rèn)知障礙。
將上述這些人與587名沒(méi)有認(rèn)知問(wèn)題的人進(jìn)行比較。結(jié)果發(fā)現(xiàn)AB型血的人在有認(rèn)知損傷的人群中占到6％的比例，高于總?cè)丝?%的比例。
雖然研究著眼于血型和認(rèn)知障礙風(fēng)險(xiǎn)的關(guān)系，但也有一些研究表明：某些因素如高血壓，高膽固醇和糖尿病，也會(huì)增加認(rèn)知障礙和老年癡呆癥的風(fēng)險(xiǎn)。此外，血型也涉及到其他如中風(fēng)等血管疾病，所以研究血型和大腦健康之間的聯(lián)系是至關(guān)重要的，目前還需要更多的研究來(lái)證實(shí)這些結(jié)果。
研究人員還研究了血液中因子VIII的濃度，VIII可幫助血液凝結(jié)。高含量的因子VIII與認(rèn)知損害和癡呆風(fēng)險(xiǎn)較高有關(guān)。 在這項(xiàng)研究中，具有較高水平因子VIII的人比蛋白質(zhì)水平較低的人，發(fā)生思維和記憶問(wèn)題的可能性高出24％。而AB型血的人與其他血型的人相比，有較高平均水平的Ⅷ因子。
原文鏈接：
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
Kristine S. Alexander, PhD, MCR, Neil A. Zakai, MD, MSc, Sarah Gillett, PhD, Leslie A. McClure, PhD, Virginia Wadley, PhD, Fred Unverzagt, PhD and Mary Cushman, MD, MSc
Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.
Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.
Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation ?30% to 68%).
Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.
該研究是一項(xiàng)大型研究，涉及超過(guò)30,000人，平均隨訪研究3.4年。這些人在研究開始時(shí)沒(méi)有記憶或思考功能問(wèn)題，但在研究過(guò)程中，研究確定了495名參與者發(fā)生思維和記憶問(wèn)題或認(rèn)知障礙。
將上述這些人與587名沒(méi)有認(rèn)知問(wèn)題的人進(jìn)行比較。結(jié)果發(fā)現(xiàn)AB型血的人在有認(rèn)知損傷的人群中占到6％的比例，高于總?cè)丝?%的比例。
雖然研究著眼于血型和認(rèn)知障礙風(fēng)險(xiǎn)的關(guān)系，但也有一些研究表明：某些因素如高血壓，高膽固醇和糖尿病，也會(huì)增加認(rèn)知障礙和老年癡呆癥的風(fēng)險(xiǎn)。此外，血型也涉及到其他如中風(fēng)等血管疾病，所以研究血型和大腦健康之間的聯(lián)系是至關(guān)重要的，目前還需要更多的研究來(lái)證實(shí)這些結(jié)果。
研究人員還研究了血液中因子VIII的濃度，VIII可幫助血液凝結(jié)。高含量的因子VIII與認(rèn)知損害和癡呆風(fēng)險(xiǎn)較高有關(guān)。 在這項(xiàng)研究中，具有較高水平因子VIII的人比蛋白質(zhì)水平較低的人，發(fā)生思維和記憶問(wèn)題的可能性高出24％。而AB型血的人與其他血型的人相比，有較高平均水平的Ⅷ因子。
原文鏈接：
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
Kristine S. Alexander, PhD, MCR, Neil A. Zakai, MD, MSc, Sarah Gillett, PhD, Leslie A. McClure, PhD, Virginia Wadley, PhD, Fred Unverzagt, PhD and Mary Cushman, MD, MSc
Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.
Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.
Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation ?30% to 68%).
Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.
